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Acta Otorhinolaryngologica Italica :... Oct 2015Cartilage tympanoplasty is an established procedure for tympanic membrane and attic reconstruction. Cartilage has been used as an ossiculoplasty material for many years.... (Review)
Review
Cartilage tympanoplasty is an established procedure for tympanic membrane and attic reconstruction. Cartilage has been used as an ossiculoplasty material for many years. The aim of this study was to evaluate hearing results of costal cartilage prostheses in ossicular chain reconstruction procedures in subjects operated on for middle ear cholesteatoma and to determine the presence of prognostic factors. Candidates for this study were patients affected by middle ear cholesteatoma whose ossicular chain was reconstructed with a chondroprosthesis. 67 cases of ossiculoplasty with total (TORP) or partial (PORP) chondroprosthesis were performed between January 2011 and December 2013. Follow-up examination included micro-otoscopy and pure tone audiometry. The guidelines of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology Head and Neck Surgery were followed and pure-tone average (PTA) was calculated as the mean of 0.5, 1, 2 and 4 kHz thresholds. Statistical analysis was performed with ANOVA tests and regression models. Average air-bone gap (ABG) significantly improved from 39.2 dB HL (SD 9.1 dB HL) to 25.4 dB HL (SD 11 dB HL) (p < 0.001). Linear regression analysis showed that the only prognostic factor was the type of operation (p = 0.02). In fact, patients submitted to ICWT presented better post-operative ABG compared to CWDT. None of the other variables influenced the results. The present study proposes costal cartilage as material of choice when autologous ossicles are not available. The maintenance of the posterior canal wall was the only prognostic factor identified.
Topics: Audiometry, Pure-Tone; Cartilage; Cholesteatoma, Middle Ear; Follow-Up Studies; Humans; Ossicular Prosthesis; Prognosis; Retrospective Studies; Treatment Outcome
PubMed: 26824916
DOI: 10.14639/0392-100X-590 -
Pathology Oncology Research : POR 2023Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in...
Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in cholangiocarcinoma. Therefore, we aimed to assess the prognostic value of tumor budding in intrahepatic and extrahepatic cholangiocarcinomas and to evaluate its correlations with other clinicopathological parameters. We monitored 219 patients who underwent surgery for intrahepatic or extrahepatic cholangiocarcinoma at the Pusan National University Hospital between 2012 and 2021. Tumor budding was evaluated using the International Tumor Budding Consensus Conference scoring system. Tumor budding was classified into low (0-4), intermediate (5-9), and high (≥10). For statistical analysis, tumor budding was divided into two groups based on the cut-off value of 10 (lower: 0-9 vs. higher: ≥10). The correlations between clinicopathological parameters were examined using the chi-square and Fisher's exact test. The prognostic values of the variables were analyzed using the log-rank test and Cox regression analysis. Low, intermediate, and high tumor buddings were identified in 135 (61.6%), 63 (28.8), and 21 (9.6%), patients, respectively. Higher tumor budding was related to the presence of lymphatic invasion ( = 0.017), higher tumor grade ( = 0.001), higher N category ( = 0.034). In the univariable and multivariable analyses, higher tumor budding was associated with shorter disease-free survival in 97 (44.3%) patients who underwent R0 resection ( < 0.001 and = 0.011). Tumor budding did not significantly correlate with disease-specific survival in entire patients. Tumor budding may serve as a prognostic factor for intrahepatic and extrahepatic cholangiocarcinomas treated with R0 resection.
Topics: Humans; Disease-Free Survival; Treatment Outcome; Bile Duct Neoplasms; Cholangiocarcinoma; Prognosis; Bile Ducts, Intrahepatic; Retrospective Studies
PubMed: 37274771
DOI: 10.3389/pore.2023.1611216 -
World Journal of Gastroenterology Jul 2010Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor. In...
Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor. In particular, lymphatic metastasis is one of the main predictors of tumor recurrence and survival, and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection. This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage, with lymph node metastasis at diagnosis. All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols, tailoring the extent of resection and the administration of preoperative and postoperative treatment. The goals of all these strategies are to improve prognosis towards the achievement of a curative resection (R0 resection) with minimal morbidity and mortality, and better postoperative quality of life.
Topics: Clinical Trials as Topic; Gastrectomy; Humans; Lymphatic Metastasis; Neoplasm Staging; Postoperative Period; Preoperative Period; Prognosis; Stomach Neoplasms; Treatment Outcome
PubMed: 20632437
DOI: 10.3748/wjg.v16.i27.3358 -
Archives of Pathology & Laboratory... Aug 2018- Tumor budding has received increasing recognition as an important independent prognostic factor in colorectal carcinoma. Prominent tumor budding in adenocarcinoma... (Review)
Review
CONTEXT
- Tumor budding has received increasing recognition as an important independent prognostic factor in colorectal carcinoma. Prominent tumor budding in adenocarcinoma arising in a polyp has been shown to be a risk factor for lymph node involvement. The variability in methods used for evaluating tumor budding in different studies and lack of standardized guidelines have impeded routine inclusion of tumor budding in pathology reports. This changed last year with consensus guidelines based on the International Tumor Budding Consensus Conference (ITBCC). These guidelines have been included in the recent College of American Pathologists (CAPs) Colorectal Cancer Protocol. The consensus methodology will allow uniform reporting of this finding, but challenges in interpretation in the setting of intense inflammation, fibrosis, or gland fragmentation need to be addressed in future guidelines.
OBJECTIVE
- To provide a brief overview of the known clinical significance of tumor budding in colorectal carcinoma and discuss the practical aspects of its implementation on a routine basis.
DATA SOURCES
- English-language pathology literature.
CONCLUSIONS
- Tumor budding has been shown to be an independent prognostic marker in colorectal carcinomas and the routine reporting of tumor buds is now advocated by using the approach outlined by the ITBCC guidelines. Tumor budding is included in the CAP protocol as a recommended element. Presence of prominent tumor budding in an adenocarcinoma in a polyp may have implications for management, such as additional resection, while it serves as a prognostic factor in other settings.
Topics: Adenocarcinoma; Clinical Decision-Making; Colorectal Neoplasms; Humans; Neoplasm Staging; Observer Variation; Practice Guidelines as Topic; Prognosis
PubMed: 30040461
DOI: 10.5858/arpa.2018-0082-RA -
Scientific Data Mar 2023Tumor microenvironment (TME) plays important roles in prognosis and immune evasion. However, the relationship between TME-related genes and clinical prognosis, immune...
Tumor microenvironment (TME) plays important roles in prognosis and immune evasion. However, the relationship between TME-related genes and clinical prognosis, immune cell infiltration, and immunotherapy response in breast cancer (BRCA) remains unclear. This study described the TME pattern to construct a TME-related prognosis signature, including risk factors PXDNL, LINC02038 and protective factors SLC27A2, KLRB1, IGHV1-12 and IGKV1OR2-108, as an independent prognostic factor for BRCA. We found that the prognosis signature was negatively correlated with the survival time of BRCA patients, infiltration of immune cells and the expression of immune checkpoints, while positively correlated with tumor mutation burden and adverse treatment effects of immunotherapy. Upregulation of PXDNL and LINC02038 and downregulation of SLC27A2, KLRB1, IGHV1-12 and IGKV1OR2-108 in high-risk score group synergistically contribute to immunosuppressive microenvironment which characterized by immunosuppressive neutrophils, impaired cytotoxic T lymphocytes migration and natural killer cell cytotoxicity. In summary, we identified a TME-related prognostic signature in BRCA, which was connected with immune cell infiltration, immune checkpoints, immunotherapy response and could be developed for immunotherapy targets.
Topics: Female; Humans; Breast Neoplasms; Drug-Related Side Effects and Adverse Reactions; Immunotherapy; Prognosis; Tumor Microenvironment
PubMed: 36869083
DOI: 10.1038/s41597-023-02032-2 -
International Journal of Medical... 2022We aimed to determine if lactate dehydrogenase to albumin ratio (LAR) might play a prognostic role for patients with operable colorectal cancer (CRC). 1334 operable...
We aimed to determine if lactate dehydrogenase to albumin ratio (LAR) might play a prognostic role for patients with operable colorectal cancer (CRC). 1334 operable CRC patients in Wuhan Union Hospital Between July 2013 and September 2017 were enrolled in this study and were randomly appointed them into training (n=954) and validation (n=380) sets. The relationship between LAR and overall survival (OS) and disease-free survival (DFS) were determined by restricted cubic splines (RCS) with Cox regression models. LAR was then divided into three categories based on the RCS and compared to the well-known TNM stage system. Finally, survival nomograms were developed by compounding the LAR and other clinical factors. Baseline LAR values and the all-cause mortality were U shaped, which slowly decreased until around 4.50 and then started to increase rapidly when the LAR ranged from 4.50-6.68 and then became flat thereafter (P for non-linearity <0.001). LAR was superior to TNM stage for OS as well as DFS and LAR plus TNM stage could add more net benefit than clinical model alone. Moreover, the survival nomograms based on LAR achieved great predictive ability for OS and DFS in operable CRC patients. : LAR could be served as a reliable prognostic factor for OS as well as DFS, with more accurate prognostic prediction than current TNM stage for patients with operable CRC.
Topics: Albumins; Colorectal Neoplasms; Humans; L-Lactate Dehydrogenase; Nomograms; Prognosis
PubMed: 35813299
DOI: 10.7150/ijms.71971 -
Aging Dec 2022Accumulated evidence has elucidated that the tumor microenvironment (TME) is great of clinical significance in predicting survival outcomes and therapeutic efficacy....
Accumulated evidence has elucidated that the tumor microenvironment (TME) is great of clinical significance in predicting survival outcomes and therapeutic efficacy. Nonetheless, few studies have investigated the prognostic and immunotherapeutic signature correlated with TME phenotypes in gastrointestinal adenocarcinomas (GIAC). Here, by estimating the TME pattern of immune infiltration and expression in over 1,000 GIAC patients, we revealed three TME subgroups and identified six key differential genes. To predict the TME phenotypes, TMEscore was established and validated to be an independent prognostic factor, where the high TMEscore was characterized by immune activation and response to immunotherapy and accompanied with favorable prognosis in GIAC. Furthermore, TMEscore was confirmed to predict prognosis and immunotherapeutic response in six datasets. In summary, depicting TME landscape of GIAC patients may be beneficial for interpreting survival and immunotherapeutic response, and provide new strategies for clinical treatment of GIAC.
Topics: Humans; Prognosis; Tumor Microenvironment; Biomarkers; Adenocarcinoma; Immunotherapy
PubMed: 36585927
DOI: 10.18632/aging.204463 -
Annals of Oncology : Official Journal... Oct 2019
Topics: Colorectal Neoplasms; Humans; Prognosis; Tumor Microenvironment
PubMed: 31504141
DOI: 10.1093/annonc/mdz294 -
Annals of Palliative Medicine Apr 2021Nowadays, controlling nutritional status (CONUT) has been used as a prognostic factor in variety of cancers. However, no consensus has been reached on the prognostic... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Nowadays, controlling nutritional status (CONUT) has been used as a prognostic factor in variety of cancers. However, no consensus has been reached on the prognostic value of CONUT in lung cancer. In this study, we aim to investigate the role of CONUT in survival of patients with lung cancer.
METHODS
EMBASE, web of science, and Medline were used to search articles in English-language journals. The association between CONUT score and survival of patients with lung cancer was evaluated by using pooled HRs and their 95% CIs. Chi-square test and I-Square was used to test heterogeneity among studies. Analyses were all performed using Stata 13.0 (Stata Corporation, College Station, TX).
RESULTS
Eight studies with 1,836 patients were eventually included in this meta-analysis. The pooled results showed that high CONUT score had an unfavorable impact on OS (HR =1.63, 95% CI: 1.30-2.04), DFS (HR =1.75, 95% CI: 1.35-2.26), CSS (HR =1.45, 95% CI: 1.01-2.07) and PFS (HR =1.67, 95% CI: 0.99-2.35), compared with those with low-CONUT.
CONCLUSIONS
CONUT can be used as a predictor of prognosis in patients with lung cancer. High-CONUT score was significantly associated with poor OS, DFS, CSS and PFS.
Topics: Humans; Lung Neoplasms; Nutritional Status; Prognosis; Retrospective Studies
PubMed: 33548999
DOI: 10.21037/apm-20-2328 -
Chirurgia (Bucharest, Romania : 1990) 2020Lymph node metastasis is regarded as an important prognostic factor for predicting disease recurrence and survival in patients with colorectal cancer. Several studies... (Review)
Review
Lymph node metastasis is regarded as an important prognostic factor for predicting disease recurrence and survival in patients with colorectal cancer. Several studies suggest that the lymph node ratio has a greater importance in survival than the number of metastatic lymph nodes. The scope of this study is to examine the 5-year survival of rectal cancer patients, examining several prognostic factors with emphasis on lymph node status. Material and A retrospective study was conducted at single surgical clinic from Romania, using data from patients who have been treated for rectal cancer between January 2009 and December 2014. Patient present status and regarding the multimodal treatment was assessed through telephonic method, data was extracted from the electronic database of the clinic and histopathological reports. A total number of 144 patients affected by rectal cancer were assessed. Statistical analysis of the variables showed that age (p=0.001), T stage(p=0.049), N stage (p=0.005), LNR (p=0.006), type of surgery (p 0.001), presence of vascular invasion (p 0.001), metastases (p 0.001), to be significant prognostic factors for survival. The 5-year survival of the patients we included in the study was 63,9%. Nodal status, expressed by lymph node ratio proved to be a significant prognostic factor of patient survival.
Topics: Databases, Factual; Humans; Lymph Node Excision; Lymph Nodes; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Rectal Neoplasms; Retrospective Studies; Romania; Treatment Outcome
PubMed: 33378633
DOI: 10.21614/chirurgia.115.6.747