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Transfusion Jun 2013Allergic transfusion reactions (ATRs) are a spectrum of hypersensitivity reactions that are the most common adverse reaction to platelets and plasma, occurring in up to... (Review)
Review
Allergic transfusion reactions (ATRs) are a spectrum of hypersensitivity reactions that are the most common adverse reaction to platelets and plasma, occurring in up to 2% of transfusions. Despite the ubiquity of these reactions, little is known about their mechanism. In a small subset of severe reactions, specific antibody has been implicated as causal, although this mechanism does not explain all ATRs. Evidence suggests that donor, product, and recipient factors are involved, and it is possible that many ATRs are multifactorial. Further understanding of the mechanisms of ATRs is necessary so that rationally designed and cost-effective prevention measures can be developed.
Topics: Blood Group Incompatibility; Blood Platelets; Blood Proteins; Humans; Hypersensitivity; Platelet Transfusion; Transfusion Reaction
PubMed: 22998777
DOI: 10.1111/j.1537-2995.2012.03892.x -
American Journal of Transplantation :... Jan 2016One component of the new national kidney allocation system (KAS) in the United States that was implemented on December 4, 2014, was the allocation of kidneys from A2 and... (Review)
Review
One component of the new national kidney allocation system (KAS) in the United States that was implemented on December 4, 2014, was the allocation of kidneys from A2 and A2 B (A, non-A1 and AB, non-A1 B) deceased donors into blood group B candidates (A2 /A2 B → B). In so far as this is an important component of the new KAS that has the potential to further increase the access to transplantation for blood group B candidates on the waiting list, most of whom are minority candidates, we will review the body of evidence and historical perspectives that led to its inclusion in the new KAS. This review will also describe prospects for more widespread use of A2 /A2 B → B transplantation and a novel mechanism of humoral immunosuppression in B patients before and after transplantation with an A2 or A2 B kidney.
Topics: ABO Blood-Group System; Blood Group Incompatibility; Humans; Kidney Transplantation; Resource Allocation; Tissue Donors; Tissue and Organ Procurement
PubMed: 26555020
DOI: 10.1111/ajt.13499 -
Nefrologia : Publicacion Oficial de La... 2010
Topics: ABO Blood-Group System; Blood Group Incompatibility; Humans; Kidney Transplantation; Living Donors
PubMed: 20038969
DOI: 10.3265/Nefrologia.pre2009.Dic.5717 -
Journal of Veterinary Internal Medicine Jan 2023
Topics: Animals; Blood Grouping and Crossmatching; Blood Group Incompatibility; Anemia, Hemolytic, Autoimmune; Agglutination
PubMed: 36598027
DOI: 10.1111/jvim.16626 -
Taiwanese Journal of Obstetrics &... May 2020We report a case of fetal hydrops and mirror syndrome in a pregnancy with anti-Jra alloimmunization.
OBJECTIVE
We report a case of fetal hydrops and mirror syndrome in a pregnancy with anti-Jra alloimmunization.
CASE REPORT
A 34-year-old multiparous woman (G3P2) at 29 weeks of gestation had complications which included generalized edema and mild dyspnea. An indirect Coombs test was positive for anti-Jra antibodies. A blood examination showed hemodilution and elevated human chorionic gonadotropin. An ultrasound examination showed fetal hydrops with cardiomegaly and polyhydramnios. The patient delivered a pale and edematous infant by cesarean section and laboratory tests showed that the neonate had severe anemia (Hb 4.4 g/dL). A direct Coombs test was also positive. Microscopic examination of the placenta revealed diffuse villous edema. A genetic test for the ABCG2 gene showed the homozygous point mutation c.376C > T (376TT) in the mother, while her three offsprings all exhibited 376CT heterozygosity.
CONCLUSION
The potential risk of severe fetal hydrops and mirror syndrome should be recognized in pregnancies with anti-Jra alloimmunization.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Adult; Anemia; Blood Group Antigens; Blood Group Incompatibility; Cesarean Section; Edema; Female; Humans; Hydrops Fetalis; Infant, Newborn; Infant, Newborn, Diseases; Isoantibodies; Neoplasm Proteins; Placenta; Point Mutation; Pregnancy; Pregnancy Complications, Hematologic; Syndrome
PubMed: 32416899
DOI: 10.1016/j.tjog.2020.03.023 -
Indian Pediatrics Aug 2021
Topics: Anemia, Hemolytic, Autoimmune; Blood Group Incompatibility; Erythroblastosis, Fetal; Humans; Infant, Newborn; Transfusion Reaction
PubMed: 34465666
DOI: No ID Found -
American Journal of Transplantation :... Jul 2014
Topics: Antibodies; Blood Group Incompatibility; Female; Graft Rejection; HLA Antigens; Humans; Kidney Transplantation; Living Donors; Male
PubMed: 24912411
DOI: 10.1111/ajt.12789 -
Anaesthesia Jan 2015The clinical practice of blood transfusion has changed considerably over the last few decades. The potential risk of transfusion transmissible diseases has directed... (Review)
Review
The clinical practice of blood transfusion has changed considerably over the last few decades. The potential risk of transfusion transmissible diseases has directed efforts towards the production of safe and high quality blood. All transfusion services now operate in an environment of ever-increasing regulatory controls encompassing all aspects of blood collection, processing and storage. Stringent donor selection, identification of pathogens that can be transmitted through blood, and development of technologies that can enhance the quality of blood, have all led to a substantial reduction in potential risks and complications associated with blood transfusion. In this article, we will discuss the current standards required for the manufacture of blood, starting from blood collection, through processing and on to storage.
Topics: Blood Banks; Blood Donors; Blood Group Incompatibility; Blood Preservation; Blood Specimen Collection; Blood Transfusion; Humans; Leukocyte Reduction Procedures
PubMed: 25440389
DOI: 10.1111/anae.12912 -
British Medical Journal May 1968
Topics: Antibodies; Blood Group Incompatibility; Erythroblastosis, Fetal; Female; Humans; Pregnancy; Rh-Hr Blood-Group System; gamma-Globulins
PubMed: 4171575
DOI: 10.1136/bmj.2.5600.300-b -
British Medical Journal Jun 1968
Topics: Blood Group Incompatibility; Female; Isoantibodies; Pregnancy; Rh-Hr Blood-Group System
PubMed: 4968789
DOI: 10.1136/bmj.2.5606.694-a