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Romanian Journal of Morphology and... 2022Sacrococcygeal teratomas (SCTs) are rare congenital tumors. With the improvement of diagnostic imaging methods and follow-up protocols in pregnancies, in utero detection... (Review)
Review
Sacrococcygeal teratomas (SCTs) are rare congenital tumors. With the improvement of diagnostic imaging methods and follow-up protocols in pregnancies, in utero detection of these tumors has increased. Despite these progresses, SCTs may present difficulties in establishing in utero diagnosis and subsequent management. We present two cases of SCT in 18 weeks, respectively 22 weeks pregnancy, diagnosed using ultrasound imaging and pathologically confirmed. Also, the article aims to recapitulate clinicopathological aspects and prognosis of these lesions, following the review of the literature.
Topics: Female; Gestational Age; Humans; Pelvic Neoplasms; Pregnancy; Prenatal Diagnosis; Sacrococcygeal Region; Spinal Neoplasms; Teratoma; Ultrasonography, Prenatal
PubMed: 36074685
DOI: 10.47162/RJME.63.1.22 -
Medical Ultrasonography Sep 2014The occurrence of a fetal tumor is rare, 50% of all fetal tumors being sacrococcygeal teratomas. Prenatal diagnosis of this condition is important for the monitoring of... (Review)
Review
The occurrence of a fetal tumor is rare, 50% of all fetal tumors being sacrococcygeal teratomas. Prenatal diagnosis of this condition is important for the monitoring of the affected fetuses and for establishing the mode and time of delivery. We describe two cases of fetal sacrococcygeal teratoma diagnosed by 2D- and 3D-ultrasound. Three-dimensional ultrasound proved to be useful both in the diagnosis and patient counseling. The combination of 2D- and 3D-ultrasound enables the diagnosis to be made during the first trimester of pregnancy.
Topics: Coccyx; Female; Humans; Imaging, Three-Dimensional; Pregnancy; Sacrum; Spinal Neoplasms; Teratoma; Ultrasonography, Prenatal
PubMed: 25110773
DOI: 10.11152/mu.2013.2066.163.mg1gi2 -
CA: a Cancer Journal For Clinicians 1988
Review
Topics: Age Factors; Child; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Infant, Newborn; Male; Prognosis; Sacrococcygeal Region; Teratoma
PubMed: 3141009
DOI: 10.3322/canjclin.38.6.362 -
Medicine Jun 2023There is currently no bibliometric study on teratomas in the literature. This study aims to analyze the published articles on teratomas to provide an overview of the... (Review)
Review
There is currently no bibliometric study on teratomas in the literature. This study aims to analyze the published articles on teratomas to provide an overview of the subject, determine global productivity, and identify current research trends. Additionally, data on different components of scientific output (countries, journals, institutions, authors) were analyzed. A total of 4209 articles published on teratomas between 1980 and 2022 were analyzed using various bibliometric and statistical methods. Bibliometric network visualization maps were used to determine trending topics, citation analyses, and international collaborations. Spearman correlation coefficient was used for correlation analysis. The top 3 countries that made the most contributions to the literature were the USA (1041, 24.7%), Japan (501, 11.9%), and India (310, 7.3%). The top 3 active institutions were the University of California System (n = 78), University of London (64), and Harvard University (62). The top 3 productive journals were the Journal of Pediatric Surgery (n = 141), Pediatric Surgery International (n = 70), and Journal of Pediatric Surgery Case Reports (69). The most productive author was Ulbright TM. (n = 18). The most studied topics from past to present were ovarian cancer/ovarian teratoma/ovarian torsion, mature cystic teratoma/dermoid cyst, sacrococcygeal teratoma, germ cell tumors, immature teratoma, malignant transformation, mediastinal teratoma/mediastinum, neonate/newborn/infant, prenatal diagnosis, testis/testicular cancer/teratoma, ultrasonography/ultrasound, magnetic resonance imaging, chemotherapy, growing teratoma syndrome, surgery, retroperitoneal teratoma/retroperitoneum, laparoscopic surgery/laparoscopy, children/child, and fetal surgery/fetus. We identified trend research topics in the field of teratomas in recent years, including mature cystic teratoma, ovarian teratoma/neoplasm, ovarian cancer, ovarian torsion, growing teratoma syndrome, recurrence, pediatric, testicular cancer, anti-n-methyl-d-aspartate receptor encephalitis, immature teratoma, retroperitoneal, struma ovarii, and carcinoid. The research leadership in the development of teratoma literature was determined by countries with major economies such as the USA, Japan, India, the UK, China, Turkey, South Korea, and other European countries (France, Germany, Italy).
Topics: Child; Female; Humans; Infant; Infant, Newborn; Male; Pregnancy; Ovarian Neoplasms; Ovarian Torsion; Teratoma; Testicular Neoplasms
PubMed: 37390229
DOI: 10.1097/MD.0000000000034208 -
Turkish Archives of Pediatrics Mar 2023Sacrococcygeal teratoma is an extragonadal germ cell tumor that develops during fetal and neonatal periods and is associated with significant perinatal morbidity and...
OBJECTIVE
Sacrococcygeal teratoma is an extragonadal germ cell tumor that develops during fetal and neonatal periods and is associated with significant perinatal morbidity and even mortality. This study aimed to determine the clinicopathologic characteristics, the clinical outcomes, and postoperative complications of sacrococcygeal teratoma cases in the low-volume pediatric surgery service in a developing country.
MATERIALS AND METHODS
The study included data from all sacrococcygeal teratoma cases diagnosed from 2011 to 2020. All the relevant clinicopathologic data were recorded and analyzed.
RESULTS
A total of 7 pediatric (5 females and 2 males) patients with sacrococcygeal teratoma were identified, ranging in age from 3 to 222 days. A prenatal diagnosis was made in 57.1% of cases. The mean gestational age for all cases was 37.1 weeks (34-38 weeks), and the mean birth weight was 3285 g (range, 2300-4700 g). Preoperative alpha-fetoprotein levels had a mean value of 24.327 ng/mL (range, 649.7-110.600 ng/mL). The surgery involved resection of the primary tumor and coccygectomy in all cases. Three (42.9%) tumors were classified as Altman type II lesions, 2 (28.6%) tumors were type IV, and 2 remaining cases were types I and III, respectively. Histology was benign in 4 (57.1%) and immature in 3 patients (42.9%). The mean follow-up time was 101.4 months (30-146 months), with 2 recurrences of high-grade immature teratomas at 11 and 30 months following the surgery. Three patients had postoperative bladder and rectal dysfunctions.
CONCLUSION
Sacrococcygeal teratomas are rare tumors associated with frequent postoperative dysfunctions. Recurrences may also be seen, particularly in immature, high-grade forms of sacrococcygeal teratomas.
PubMed: 36856354
DOI: 10.5152/TurkArchPediatr.2023.22268 -
Indian Journal of Thoracic and... Jan 2022Teratomas are tumors consisting of tissues derived from more than one germ cell line. Usual locations are sacrococcygeal region, intracranial, mediastinum, and gonads....
Teratomas are tumors consisting of tissues derived from more than one germ cell line. Usual locations are sacrococcygeal region, intracranial, mediastinum, and gonads. Entirely intrapulmonary teratomas, with no mediastinal component, are rarely reported. We present the case of a 37-year-old man who presented for evaluation due to persistent and progressive intermittent cough. There was no sputum or hemoptysis. Computed tomography (CT) revealed an irregular, cystic lesion in the upper lobe of his left lung, which raised suspicion for aspergilloma. The patient underwent a left thoracotomy and, after finding a completely collapsed and hypoplastic left lung almost entirely occupied by an irregular mass, a total left pneumonectomy was performed. Pathological review reported an entirely intrapulmonary mature teratoma. Intrapulmonary mature teratomas are extremely rare, although several have been reported. Trichoptysis (expectoration of hair) is a specific finding that may help distinguish this entity from mediastinal teratomas.
PubMed: 34898881
DOI: 10.1007/s12055-021-01180-7 -
Human Genome Variation Nov 2020Tuberous sclerosis complex (TSC) is an autosomal dominant disease associated with tumors and malformed tissues in the brain and other vital organs. We report a novel de...
Tuberous sclerosis complex (TSC) is an autosomal dominant disease associated with tumors and malformed tissues in the brain and other vital organs. We report a novel de novo frameshift variant of the TSC1 gene (c.434dup;p. Ser146Valfs*8) in a child with TSC who initially presented with a sacral teratoma. This previously unreported association between TSC and teratoma has broad implications for the pathophysiology of embryonic tumors and mechanisms underlying cellular differentiation.
PubMed: 33298910
DOI: 10.1038/s41439-020-00124-8 -
Ultrasound in Obstetrics & Gynecology :... Jun 2016The objectives of this study were to evaluate the efficacy of minimally invasive ablation of high-risk large sacrococcygeal teratomas (SCT) and to compare the efficacy... (Review)
Review
OBJECTIVES
The objectives of this study were to evaluate the efficacy of minimally invasive ablation of high-risk large sacrococcygeal teratomas (SCT) and to compare the efficacy of vascular and interstitial tumor ablation.
METHODS
This was a retrospective multicenter study including a cohort of fetuses with high-risk large SCTs between 2004 and 2010. In addition, we performed a systematic literature review of all cases that underwent tumor ablation in order to compare the survival rates after 'vascular' and 'interstitial' ablation. Statistical analysis was conducted using Bayesian methods.
RESULTS
In our cohort, a total of 13 fetuses had high-risk large SCT and five of them underwent tumor ablation. The estimated difference in hydrops resolution rate between the fetal intervention and the no fetal intervention groups was 44.6% (95% credibility interval, 1.5 to 81.0%; Pdiff> 0 = 97.9%). The estimated difference in survival rate between the fetal intervention and the no fetal intervention groups was 31.0% (13.9 to 48.1%; Pdiff> 0 = 99.9%). We analyzed our five cases together with 28 cases from the literature and estimated the difference in survival rate between the vascular and interstitial ablation groups as 19.8% (-13.1 to 50.1%; Pdiff> 0 = 88.3%). The estimated difference in hydrops resolution rate between the vascular and the interstitial ablation groups was 36.7% (-5.7 to 72.7%; Pdiff> 0 = 95.5%).
CONCLUSION
Minimally invasive surgery seems to improve perinatal outcome in cases of high-risk large fetal SCT. Our findings suggest that 'vascular' ablation may improve outcome and may be more effective than 'interstitial' tumor ablation, but this hypothesis needs further investigation in a larger multicenter prospective study. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.
Topics: Ablation Techniques; Cohort Studies; Female; Fetal Therapies; Humans; Minimally Invasive Surgical Procedures; Pregnancy; Retrospective Studies; Sacrococcygeal Region; Spinal Neoplasms; Survival Analysis; Teratoma; Treatment Outcome
PubMed: 26138446
DOI: 10.1002/uog.14935 -
BMJ Case Reports Feb 2023Teratomas in the neonatal age group are mostly benign at first, and the common site is the sacrococcygeal region. They are rarely associated with HIV infection. We...
Teratomas in the neonatal age group are mostly benign at first, and the common site is the sacrococcygeal region. They are rarely associated with HIV infection. We report a case of an HIV-exposed newborn with a congenital teratoma at the post-auricular site who developed an infection. Early intervention by total surgical resection will prevent complications such as infections and malignant transformation. A term baby was delivered spontaneously by an HIV-positive mother who was on her regular medications. Prenatal ultrasound carried out in the third trimester showed a cyst swelling on the right post-auricular region. Radiological imaging and the histopathological result revealed a congenital teratoma. A wide major excision with preservation of the facial nerve was performed at the age of 8 weeks. Post-auricular teratomas are the rarest anatomical location and the prevalence of malignant transformation from benign is very low. If left untreated, this tumour is associated with high mortality and malignant transformation rates. An early complete surgical excision allows a good result with a low risk of complications and recurrence.
Topics: Infant; Infant, Newborn; Pregnancy; Female; Humans; HIV Infections; Teratoma; Mothers; Sacrococcygeal Region; Cell Transformation, Neoplastic
PubMed: 36746517
DOI: 10.1136/bcr-2022-252977 -
Cureus Sep 2022Congenital thyroid teratomas are rare in the pediatric population as well as in the adult population. While they are typically found in the gonadal regions,...
Congenital thyroid teratomas are rare in the pediatric population as well as in the adult population. While they are typically found in the gonadal regions, extragonadally, they are commonly found in the sacrococcygeal region, with teratomas of the head and neck rarely found, comprising only about 1%-6% of all pediatric teratomas. Due to a concern for potential airway compromise and increased risk of malignancy with age, early surgical excision is recommended. In this case report, we present a two-year-old female who underwent laryngoscopy with subsequent right thyroid lobectomy for a large thyroid mass, which was found to be a congenital thyroid teratoma.
PubMed: 36304375
DOI: 10.7759/cureus.29395