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International Journal of Applied &... 2021Recurrent chalazion may be associated with bad lid hygiene but can have clinical changes which lead to the suspicion of a more dangerous entity. Particularly in elderly...
Recurrent chalazion may be associated with bad lid hygiene but can have clinical changes which lead to the suspicion of a more dangerous entity. Particularly in elderly patients, recurrence of chalazion should be suspected to have carcinomatous changes. We present the case of a 52-year-old woman with presentation of recurrent chalazion which turned out to be sebaceous gland carcinoma of the lid. Sebaceous gland carcinoma usually presents as a small firm nodule resembling chalazion, and majority of the premalignant and malignant lesions misdiagnosed as chalazion are primary cases. Hence, the need of histopathological examination in every such case cannot be undermined.
PubMed: 33912435
DOI: 10.4103/ijabmr.IJABMR_652_20 -
GLUT1 Expression in Cutaneous Sebaceous Lesions Determined by Immunohistochemical Staining Patterns.Dermatopathology (Basel, Switzerland) Jul 2021GLUT1 is a membrane associated carrier protein that functions in the physiologic transport of glucose across cell membranes. Multiple studies have shown an increased...
GLUT1 is a membrane associated carrier protein that functions in the physiologic transport of glucose across cell membranes. Multiple studies have shown an increased GLUT1 expression in various tumor types and a role in cancer prognosis. The aim of this study was to determine whether cutaneous sebaceous lesions have a differential expression of GLUT1 by immunohistochemistry (IHC). GLUT1 IHC was performed on excision specimens of ten cases of sebaceous carcinoma, nine of sebaceoma, ten of sebaceous adenoma, and ten of sebaceous hyperplasia. Intense, diffuse cytoplasmic staining was observed in sebaceous carcinoma. The pattern of GLUT1 staining in sebaceomas and sebaceous adenomas consisted of a gradient of intense cytoplasmic staining in the basaloid cells with a decreased intensity to membranous staining only and absent staining in mature sebaceous cells. In lesions of sebaceous hyperplasia, GLUT1 staining outlined the basal layer of each gland; cytoplasmic staining was minimal to absent. Increased cytoplasmic staining of GLUT1 may correlate with cellular metabolic and proliferative activity. GLUT1 has potential utility in differentiating sebaceous lesions.
PubMed: 34287324
DOI: 10.3390/dermatopathology8030031 -
Annals of Translational Medicine May 2022Ultraviolet (UV) exposure is the most essential etiological factor in sebaceous gland carcinoma (SGC). The abnormal expression of microRNAs (miRNAs) is also involved in...
BACKGROUND
Ultraviolet (UV) exposure is the most essential etiological factor in sebaceous gland carcinoma (SGC). The abnormal expression of microRNAs (miRNAs) is also involved in SGC. However, the function of miRNAs in UV-induced SGC is still unclear.
METHODS
In this study, the expression levels of miR-651-5p and zinc finger E-box binding homeobox 2 () in SGC tissues and cells were measured by real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting. Then, the effects of miR-651-5p on the apoptosis, migration, invasion, and epithelial-mesenchymal transition (EMT) of UV-induced SGC cells were determined. The interactions between miR-651-5p and were verified by a dual-luciferase reporter assay. An tumor growth assay was performed to assess tumorigenicity.
RESULTS
The results showed that there was abnormal expression of miR-651-5p and in SGC tissues and cells compared with the control tissues and cells. Overexpression of miR-651-5p and knockdown of inhibited the malignant biological behaviors of SGC cells. Moreover, is one of the target genes of miR-651-5p, and the expression of was negatively regulated by miR-651-5p in SGC cells. Further studies showed that overexpression of miR-651-5p promoted cell apoptosis and inhibited the cell invasion and migration ability and EMT of UV-induced SGC cells by downregulating the expression of ZEB2 and .
CONCLUSIONS
This study revealed that overexpression of miR-651-5p inhibited UV-induced SGC growth and metastasis by suppressing , which may be a potential target for SGC prevention and therapy.
PubMed: 35928738
DOI: 10.21037/atm-21-3897 -
Bulletin of the World Health... 1974Tumours occur more frequently in the skin than in any other part of the body. Epithelial tumours are described under the following headings: basal cell tumour, squamous...
Tumours occur more frequently in the skin than in any other part of the body. Epithelial tumours are described under the following headings: basal cell tumour, squamous cell carcinoma, papilloma, sebaceous gland tumour, tumour of hepatoid glands, sweat gland tumour, mixed tumour of apocrine sweat glands, carcinoma of apocrine sweat glands, tumour of hair follicle, and intracutaneous cornifying epithelioma. Tumours of the melanogenic system are divided into benign melanoma and malignant melanoma, the latter being subdivided into the following types: epithelioid, spindle cell, epithelioid and spindle cell, dendritic, and whorled.
Topics: Adenoma; Animals; Animals, Domestic; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cats; Cattle; Dermoid Cyst; Dogs; Epidermal Cyst; Goats; Hair; Keratoacanthoma; Melanoma; Papilloma; Sebaceous Gland Neoplasms; Sheep; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 4547652
DOI: No ID Found -
Journal of Maxillofacial and Oral... Dec 2019Sebaceous gland carcinoma of the eyelid is an uncommon but highly malignant tumour. Post-tumour excisional defect reconstruction must aim in restoration of function and...
INTRODUCTION
Sebaceous gland carcinoma of the eyelid is an uncommon but highly malignant tumour. Post-tumour excisional defect reconstruction must aim in restoration of function and aesthetics. Prompt diagnosis and adequate treatment is of paramount for successful outcome of disease.
CASE REPORT
A 61-year-old female patient underwent surgery for sebaceous gland carcinoma of right lower eyelid 3 years back and reported to us with recurrence. On examination, an exophytic mass was seen over right conjunctiva adjacent to the eyelid margin. With the objective of restoring form and aesthetics, immediate reconstruction was carried out using superiorly pedicled nasolabial flap to cover the lower eyelid defect and non-vascularised buccal mucosal flap for bulbar and palpebral conjunctival reconstruction.
CONCLUSION
The tumour is notorious to cause local recurrence and metastases; hence, an early and accurate diagnosis, surgical and adjunctive chemoradiation and regular periodic follow-ups are of utmost importance for the successful management of sebaceous gland carcinoma of eyelids.
PubMed: 31624431
DOI: 10.1007/s12663-018-1171-7 -
Diagnostics (Basel, Switzerland) Nov 2020A 16-year-old male patient underwent F-FDG PET/CT staging after multiple surgical resections and radiotherapy of an uncommon metastatic pediatric sebaceous carcinoma of...
A 16-year-old male patient underwent F-FDG PET/CT staging after multiple surgical resections and radiotherapy of an uncommon metastatic pediatric sebaceous carcinoma of the parotid gland. Initial PET/CT imaging exhibited a recurrent paravertebral metastasis (C4) as well as a metabolically active tumor tissue at the primary site. Follow-up PET/CT after radiotherapy of the cervical spine (C4) and four cycles of chemotherapy with cisplatin and palbociclib revealed complete functional remission in the cervical spine and partial remission at the primary site. This case illustrates the F-FDG-uptake behavior and the disease course of a very rare malignant epithelial tumor of the salivary glands.
PubMed: 33172066
DOI: 10.3390/diagnostics10110908 -
Journal of Surgical Oncology Mar 2022Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long-term data are scarce. This study aimed to assess the outcome of patients treated with...
BACKGROUND
Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long-term data are scarce. This study aimed to assess the outcome of patients treated with resection for SC.
METHODS
Patients treated at four tertiary centres were included. Cumulative incidence curves were calculated for recurrences.
RESULTS
A total of 100 patients (57 males, 57%) were included with 103 SCs. The median age was 72 (range, 15-95) years with a median follow-up of 52 (interquartile range [IQR], 24-93) months. Most SCs were located (peri)ocular (49.5%). Of all SCs, 17 locally recurred (16.5%) with a median time to recurrence of 19 (IQR, 8-29) months. The cumulative incidence probability for recurrence was statistically higher for (peri)ocular tumours (p = 0.005), and for positive resection margins (p = 0.001). Two patients presented with lymph node metastases and additional seven patients (8.7%) developed lymph node metastases during follow-up with a median time to metastases of 8 (IQR, 0.5-28) months. Three patients had concurrent in-transit metastases and one patient also developed liver and bone metastases during follow-up.
CONCLUSION
SC is a rare, yet locally aggressive tumour. Positive resection margins and (peri)ocular SCs are more frequently associated with local recurrence. SC infrequently presents with locoregional or distant metastases.
Topics: Adenocarcinoma, Sebaceous; Adolescent; Adult; Aged; Aged, 80 and over; Eye Neoplasms; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Sebaceous Gland Neoplasms; Young Adult
PubMed: 34990031
DOI: 10.1002/jso.26774 -
Histopathology Jan 2010Sebaceous neoplasia comprises a spectrum ranging from benign to malignant. Proper histological identification is important for treatment, prognosis and potential... (Review)
Review
Sebaceous neoplasia comprises a spectrum ranging from benign to malignant. Proper histological identification is important for treatment, prognosis and potential association with the Muir-Torre syndrome (MTS). Our increased understanding of the significance and pathogenesis of these tumours has led to improved risk stratification, screening recommendations, and treatment of patients with an initial presentation of a sebaceous tumour. This review focuses on the diagnostic and histological features of sebaceous lesions, the MTS, and recent insights into the molecular pathogenesis of sebaceous tumours.
Topics: Adenocarcinoma, Sebaceous; Adenoma; Humans; Muir-Torre Syndrome; Sebaceous Gland Neoplasms
PubMed: 20055911
DOI: 10.1111/j.1365-2559.2009.03454.x -
Dermatologic Surgery : Official... Aug 2022Sebaceous adenocarcinoma (SAC) mostly occurs in the elderly, and SAC in young and middle-aged population is inadequately investigated.
BACKGROUND
Sebaceous adenocarcinoma (SAC) mostly occurs in the elderly, and SAC in young and middle-aged population is inadequately investigated.
OBJECTIVE
To explore the clinical features and prognosis of young and middle-aged adults with SAC.
MATERIALS AND METHODS
Patients with skin SAC between ages 18 and 59 years from the Surveillance, Epidemiology, and End Results database (1975-2016) were eligible for this study.
RESULTS
Seven hundred thirty-nine cases were identified. The proportion of extraocular SAC in the nonelderly increased from 1975-2005 to 2006-2016 ( p = .001), male predominance was observed in overall patients whereas female predominance in Asian population, and young patients had more head and neck SAC than middle-aged patients ( p = .014). The prognosis of young patients was better than middle-aged patients ( p = .004). Other independent prognostic factors included sex, marital status, tumor size, surgery, chemotherapy, and multiple primary cancer history.
CONCLUSION
An increasing proportion of extraocular SAC was observed in young and middle-aged patients, and the young developed more head and neck SAC than the middle-aged. Female predominance was found in Asian population, and female patients had better prognosis. Younger age and married status indicated better prognosis, and around 20% of young and middle-aged patients might have poorer survival because of Muir-Torre syndrome.
Topics: Adenocarcinoma, Sebaceous; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Muir-Torre Syndrome; Prognosis; Sebaceous Gland Neoplasms; Skin; Young Adult
PubMed: 35917259
DOI: 10.1097/DSS.0000000000003506 -
Indian Journal of Dermatology,... 2012Skin tumors are tumors arising from keratinocyte and from adnexal structures. Immunohistochemistry is very helpful in diagnosis of difficult cases in epithelial skin... (Review)
Review
Skin tumors are tumors arising from keratinocyte and from adnexal structures. Immunohistochemistry is very helpful in diagnosis of difficult cases in epithelial skin neoplasms, especially basal cell carcinoma (BCC) which is positive for BerEP4, a keratin marker, and mostly negative for epithelial membrane antigen (EMA). Squamous cell carcinoma cells are positive for EMA and cytokeratin, which are of higher molecular weight than those found in BCC. In contrast to BCC, trichoblastoma and trichoepithelioma are negative for androgen receptors. Of the malignant dermal spindle cell lesions, spindle cell squamous carcinoma is positive to 34 betaE12, desmoplasmic melanoma is positive to S100, and leiomyosarcoma is positive to desmin. Of the malignant pagetoid cells, Paget's disease is positive to CK7 and cam5.2, whereas the pagetoid variant of Bowen's disease is positive to CK 5/6. Melanoma in-situ is positive to both S100 and melan-A. Immunohistochemistry is an extremely valuable adjunct to standard morphologic diagnosis in diagnostic pathology. Diagnosis of epithelial tumor depends largely on morphological features but, in rare cases, immunohistochemical stains are needed for definitive diagnosis.
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Hair Diseases; Hair Follicle; Humans; Immunohistochemistry; Keratoacanthoma; Keratosis, Actinic; Melanoma; Sebaceous Gland Neoplasms; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 23075638
DOI: 10.4103/0378-6323.102359