Pharmacologic Substance
zoledronic acid
[ zoh-leh-drah-nik a-sid ]
Brand Names:
Reclast; Zometa
Effect:
Bone Resorption Inhibition
May Treat:
Bone Neoplasms;
Hypercalcemia;
Multiple Myeloma;
Paget Disease, Extramammary
More Information:
Definitions related to zoledronic acid:
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A drug used to treat patients with hypercalcemia (high blood levels of calcium) caused by cancer. It is also used together with other drugs to treat multiple myeloma and to prevent bone fractures and reduce bone pain in people who have cancer that has spread to the bone. It is a type of bisphosphonate.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia.NCI ThesaurusU.S. National Cancer Institute, 2021
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An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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