Antibiotic
becatecarin
Definitions related to becatecarin:
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A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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(rebeccamycin analog) A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called antitumor antibiotics and topoisomerase inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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