Pharmacologic Substance
bretylium tosylate
Effect:
Atrial Repolarization; Negative Chronotropy; Ventricular Repolarization
May Prevent:
Ventricular Fibrillation
May Treat:
Tachycardia, Ventricular;
Ventricular Fibrillation
More Information:
Definitions related to bretylium tosylate:
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An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The tosylate salt form of bretylium, a quaternary ammonium salt and non-selective adrenergic neuronal blocking agent with anti-arrhythmic properties. Bretylium tosylate is selectively taken up into peripheral nerve terminals and initially causes a release of norepinephrine from sympathetic nerve endings, thereby causing a sympathomimetic effect. This is followed by a prolonged anti-adrenergic action which prevents further discharge of neurotransmitter from sympathetic nerve endings. Its myocardial effects include a prolongation of action potential as well as refractory period. This drug is used to treat and suppress ventricular arrhythmias, particularly ventricular fibrillation and ventricular tachycardia.NCI ThesaurusU.S. National Cancer Institute, 2021
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