Pharmacologic Substance
carvedilol
Brand Names:
Coreg
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Negative Chronotropy; Negative Inotropy
May Treat:
Angina Pectoris;
Heart Failure;
Hypertension;
Myocardial Infarction
More Information:
Definitions related to carvedilol:
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A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A drug used to treat high blood pressure and certain heart problems. It is also being studied in the prevention and treatment of side effects caused by some anticancer drugs. Coreg blocks certain receptors on nerve cells and causes blood vessels to dilate (widen). It is a type of antihypertensive agent and a type of antianginal agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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