Pharmacologic Substance
cyclophosphamide
cy·clo·phos·pha·mide [ sahy-kluh-fos-fuh-mahyd, -mid, sik-luh- ]
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Anemia, Hemolytic, Autoimmune;
Breast Neoplasms;
Burkitt Lymphoma;
Endometrial Neoplasms;
Granulomatosis with Polyangiitis;
Hemosiderosis;
Hodgkin Disease;
Leukemia, Lymphocytic, Chronic, B-Cell;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Leukemia, Myeloid, Acute;
Lung Neoplasms;
Lupus Nephritis;
Multiple Myeloma;
Multiple Sclerosis;
Myasthenia Gravis;
Mycosis Fungoides;
Nephrotic Syndrome;
Neuroblastoma;
Ovarian Neoplasms;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Purpura, Thrombocytopenic, Idiopathic;
Red-Cell Aplasia, Pure;
Retinoblastoma;
Rhabdomyosarcoma;
Rheumatic Diseases;
Sarcoma, Ewing;
Testicular Neoplasms;
Waldenstrom Macroglobulinemia
More Information:
Definitions related to cyclophosphamide:
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A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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