Pharmacologic Substance
desonide
Brand Names:
Desonate; Desowen; Desrx; Lokara; Tridesilon; Verdeso
Effect:
Antipruritic Activity; Decreased Immunologically Active Molecule Activity; Decreased Protein Synthesis; Vasoconstriction
May Treat:
Facial Dermatoses;
Foot Dermatoses;
Hand Dermatoses;
Inflammation;
Leg Dermatoses;
Scalp Dermatoses
More Information:
Definitions related to desonide:
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A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.NCI ThesaurusU.S. National Cancer Institute, 2021
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