Pharmacologic Substance
eflornithine
Brand Names:
Vaniqa
Effect:
Cellular Growth Phase Alteration; Decreased DNA Replication; Decreased Protein Synthesis; Decreased RNA Replication
May Treat:
Hypertrichosis;
Trypanosomiasis, African
More Information:
Definitions related to eflornithine:
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A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(difluoromethylornithine) Polyamine antagonist which reversibly inhibits DNA polymerase and irreversibly inhibits ornithine decarboxylase; used against bladder cancer, with potential applications in epilepsy and PCP withdrawal.CRISP ThesaurusNational Institutes of Health, 2006
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Eflornithine, drug used to treat late-stage African trypanosomiasis (sleeping sickness). Eflornithine is effective only against Trypanosoma brucei gambiense, which causes Gambian (or West African) sleeping sickness. It is not effective against T. brucei rhodesiense, which causes Rhodesian (or East...Encyclopedia Britannica, Inc., 2020
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