Antibiotic
gentamicin
gen·ta·mi·cin [ jen-tuh-mahy-sin ]
Brand Names:
Betagen brand of Betamethasone and Gentamicin; Easotic; Garasol; Genone; Gentacalm; Gentak; GentaVed; Gentaved 100; Legacy; LoZatom; Malotic; Mometamax; Motazol; Otomax; Pattotic; Pred-G; Relifor; Tri-Otic for Canines; Vetromax
Effect:
Decreased Cell Membrane Integrity; Decreased Protein Synthesis
May Prevent:
Endocarditis, Bacterial
May Treat:
Bone Diseases, Infectious;
Central Nervous System Infections;
Endocarditis;
Escherichia coli Infections;
Eye Infections, Bacterial;
Klebsiella Infections;
Peritonitis, Tuberculous;
Proteus Infections;
Pseudomonas Infections;
Respiratory Tract Infections;
Sepsis;
Serratia Infections;
Skin Diseases, Bacterial;
Soft Tissue Infections;
Staphylococcal Infections;
Urinary Tract Infections
More Information:
Definitions related to gentamicin:
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A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.NCI ThesaurusU.S. National Cancer Institute, 2021
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A complex of closely related aminoglycoside bases (e.g., Gentamicins C1, C2, and C1(subA)), obtained from MICROMONOSPORA purpurea and related species.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Complex of three different closely related aminoglycoside sulfates, obtained from Micromonospora purpurea and related species; broad-spectrum antibiotics; may cause ear and kidney damage; they act to inhibit protein synthesis.CRISP ThesaurusNational Institutes of Health, 2006
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