Pharmacologic Substance
lamivudine
[ luh-mih-vyoo-deen ]
Brand Names:
Cimduo; Combivir; Delstrigo; Dovato; Epivir; Epivir HBV; Epzicom; Symfi; Temixys; Triumeq; Trizivir
Effect:
Decreased Reverse Transcription to DNA; Increased Immunologically Active Molecule Activity
May Treat:
Acquired Immunodeficiency Syndrome
More Information:
Definitions related to lamivudine:
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A drug used to treat infection caused by viruses.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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