Pharmacologic Substance
mifepristone
mi·fep·ri·stone [ mif-uh-pris-tohn ]
Brand Names:
Korlym; Mifeprex
Effect:
Decreased Ovarian Progesterone Secretion
May Treat:
Brain Neoplasms;
Hyperglycemia;
Meningeal Neoplasms;
Pregnancy, Ectopic
More Information:
Definitions related to mifepristone:
-
11-((4-dimethylamino) phenyl)-17-hydroxy-17-(1-propynyl) estra-4,9- dien-3-one; progesterone and glucocorticoid antagonist with potential applications in terminating pregnancy, controlling menstruation, and treating hypercortisolism.CRISP ThesaurusNational Institutes of Health, 2006
-
A derivative of the synthetic progestin norethindrone with antiprogesterone activity. Mifepristone competitively binds to the progesterone receptor, resulting in inhibition of the effects of endogenous or exogenous progesterone. This agent also exhibits antiglucocorticoid and weak antiandrogenic activities.NCI ThesaurusU.S. National Cancer Institute, 2021
-
A drug used to end early pregnancies. It is also being studied in the treatment of some types of cancer and other conditions. Mifepristone blocks the action of progesterone, a hormone that helps some cancers grow. It is a type of antiprogesterone.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
-
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
-
Mifepristone, synthetic steroid drug used under various trade names (e.g., RU-486, Mifegyne, Mifeprex) to induce abortion in the early weeks of pregnancy. Mifepristone is an antiprogestin; that is, it blocks the action of progesterone, a naturally produced hormone that prepares the inner lining of...Encyclopedia Britannica, Inc., 2020
Return to OpenMD Medical Dictionary
> M
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.