Pharmacologic Substance
mitoguazone
Subclass of:
Guanidines
Definitions related to mitoguazone:
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A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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