Pharmacologic Substance
pantoprazole
Brand Names:
Protonix
Effect:
Inhibition Gastric Acid Secretion
May Treat:
Esophagitis;
Gastroesophageal Reflux;
Heartburn;
Helicobacter Infections;
Zollinger-Ellison Syndrome
More Information:
Definitions related to pantoprazole:
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2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A substituted benzimidazole and proton pump inhibitor with antacid activity. Pantoprazole is a lipophilic weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulphenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.NCI ThesaurusU.S. National Cancer Institute, 2021
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