Disease or Syndrome
Aicardi's syndrome
Subclass of:
Agenesis of corpus callosum;
Genetic Diseases, X-Linked;
Eye Diseases, Hereditary;
Congenital Abnormality
Definitions related to aicardi's syndrome:
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(aicardi syndrome) A rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM, resulting in infantile spasms, MENTAL RETARDATION, and lesions of the RETINA or OPTIC NERVE.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(aicardi syndrome) A sporadic genetic syndrome characterized by agenesis of the corpus callosum, infantile spasms, and chorioretinal lacunae. It is associated with the presence of choroid plexus neoplasms in the brain.NCI ThesaurusU.S. National Cancer Institute, 2021
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Aicardi syndrome is a neurodevelopmental disorder that affects primarily females. Initially it was characterized by a typical triad of agenesis of the corpus callosum, central chorioretinal lacunae, and infantile spasms. As more affected individuals have been ascertained, it has become clear that not all affected girls have all three features of the classic triad and that other neurologic and systemic defects are common, including other brain malformations, optic nerve abnormalities, other seizure types, intellectual disability of varying severity, and scoliosis.GeneReviewsUniversity of Washington, 2021
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In 1965, a French neurologist, Dr Jean Dennis Aicardi, described 8 children with infantile spasm-in-flexion, total or partial agenesis of the corpus callosum, and variable ocular abnormalities. This clinical scenario, already reported in 1949, was recognized as an entity distinct from congenital infections.WebMD, 2019
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Aicardi syndrome is a rare neurological disorder. The severity of the syndrome and the associated signs and symptoms vary from person to person. The three main features of Aicardi syndrome are: Complete or partial absence of the nerve tissue that allows the right and left sides of the brain to communicate (corpus callosum) Seizures...National Center for Advancing Translational Sciences
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