Disease or Syndrome
Cobb syndrome
Cobb syn·drome
Definitions related to cobb syndrome:
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A rare congenital but non-hereditary disorder characterized by angiomas or arteriovenous malformations of the spinal cord. Clinical signs include sudden onset of radicular pain localizable to a dermatome with overlying cutaneous vascular lesions. Untreated, the clinical course follows a progression of sensory loss, weakness to paralysis and incontinence. However, clinical prognosis improves with endovascular embolization and/or surgical excision of the spinal lesion.NCI ThesaurusU.S. National Cancer Institute, 2021
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(spinal arteriovenous metameric syndrome) Cobb syndrome is defined by the association of vascular cutaneous (venous or arteriovenous), muscular (arteriovenous), osseous (arteriovenous) and medullary (arteriovenous) lesions at the same metamere or spinal segment. This segmental distribution may involve one or many of the 31 metameres present in humans. Only 16% of the medullary lesions are multiple and have a clearly metameric distribution.OrphaNetINSERM, 2021
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Cobb syndrome is a rare, noninherited disorder that involves the association of spinal angiomas or arteriovenous malformations (AVM) with congenital, cutaneous vascular lesions in the same dermatome. Berenbruch first described the disorder in 1890, but it was not widely known until Cobb's report in 1915.WebMD, 2019
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Cobb syndrome is defined by the association of vascular cutaneous (venous or arteriovenous), muscular (arteriovenous), osseous (arteriovenous) and medullary (arteriovenous) lesions at the same metamere or spinal segment. This segmental distribution may involve one or many of the 31 metameres present in humans. Only 16% of the medullary...National Center for Advancing Translational Sciences
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