Genetic Function
DNA repair
DNA re·pair
Definitions related to dna repair:
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Enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage.NCI ThesaurusU.S. National Cancer Institute, 2021
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Reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions; the major repair mechanisms are excision repair, photoreactivation repair, and post-replication repair.CRISP ThesaurusNational Institutes of Health, 2006
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The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.Gene Ontology DictionaryGene Ontology Consortium, 2021
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The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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