Disease or Syndrome
Lynch syndrome
Lynch syn·drome
Also called:
Hereditary Nonpolyposis Colorectal Carcinoma; HNPCC
Definitions related to lynch syndrome:
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An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing endometrial carcinoma, gastric carcinoma, ovarian carcinoma, renal pelvis carcinoma, and small intestinal carcinoma. Patients often develop colorectal carcinomas at an early age (mean, 45 years). In the majority of the cases the lesions arise from the proximal colon. At the molecular level, high-frequency microsatellite instability is present.NCI ThesaurusU.S. National Cancer Institute, 2021
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Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.GeneReviewsUniversity of Washington, 2021
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Lynch syndrome is an autosomal dominant disorder responsible for 2 to 3% of cases of colorectal cancer. Symptoms, initial diagnosis, and treatment are similar to other forms of colorectal cancer. Lynch syndrome is suspected by history and is confirmed by genetic testing. Patients also require surveillance for other cancers, particularly...Merck & Co., Inc., 2020
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