Disease or Syndrome
Mikulicz disease
Subclass of:
Salivary Gland Diseases
Definitions related to mikulicz disease:
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A rare, persistent and bilateral enlargement of the lacrinmal and salivary glands associated with lymphocytic infiltration of the affected glands. It is not associated with other systemic diseases.NCI ThesaurusU.S. National Cancer Institute, 2021
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(mikulicz' disease) A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(igg4-related dacryoadenitis and sialadenitis) IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis.OrphaNetINSERM, 2021
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