Immunologic Factor
T-cell receptor
Subclass of:
Receptors, Antigen
Definitions related to t-cell receptor:
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Heterodimeric antigen receptors present on the surface of T-cells. Two T-cell antigen receptors have been identified, consisting of heterodimeric 40-55 kD Ig-like alpha/beta or gamma/delta integral membrane glycoproteins. Genes for TCR alpha, beta, gamma, and delta subunits are assembled during T-cell development by somatic rearrangement of germline gene segments, resembling B-cell Ig genes in their mechanisms of diversity generation and activation of expression. Alpha/beta heterodimers are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented by MHC gene products. T-cells expressing gamma/delta heterodimers directly recognize proteins and non-proteinacious phospho-ligands. T-cell receptors are non-covalently associated with CD3, forming the TCR-CD3 complex. TCRs activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. (from OMIM and NCI)NCI ThesaurusU.S. National Cancer Institute, 2021
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(t cell receptor) Immunoglobulin like receptor associated with CD3 marker on T lymphocytes which binds specific antigen and thereby participates in T cell activation; recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen receptor structure, composed of either alpha-beta or gamma-delta chains.CRISP ThesaurusNational Institutes of Health, 2006
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(receptors, antigen, t-cell) Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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