• (ace inhibitor) A pharmaceutical agent that inhibits angiotensin-converting enzyme (ACE), which catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis. It is primarily used for the reduction of proteinuria and the treatment of hypertension.
  NICHD Pediatric Terminology
  U.S. National Cancer Institute, 2021
• (ace inhibitor) Any substance that inhibits angiotensin-converting enzyme (ACE), an enzyme that catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis.
  NCI
  U.S. National Cancer Institute, 2021
• (ace inhibitor) Class of antihypertensive agents which act by inhibiting the proteolytic activation of angiotensin.
  CRISP Thesaurus
  National Institutes of Health, 2006
• A drug that is used to lower blood pressure. An ACE inhibitor is a type of antihypertensive agent.
  NCI Dictionary of Cancer Terms
  U.S. National Cancer Institute, 2021
• A drug used to treat high blood pressure and congestive heart failure. These drugs stop the production of angiotensin II. This lowers blood pressure and reduces the heart's workload. Usually abbreviated as ACE inhibitor.
  Harvard Dictionary of Health Terms
  Harvard Medical Publishing, 2011
• A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2025