Pharmacologic Substance
proteasome inhibitor Audio
[ proh-tee-uh-some in-hih-bih-ter ]
Subclass of:
Protease Inhibitors
Definitions related to proteasome inhibitor:
  • A drug that blocks the action of proteasomes. A proteasome is a large protein complex that helps destroy other cellular proteins when they are no longer needed. Proteasome inhibitors are being studied in the treatment of cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis.
    NCI
    U.S. National Cancer Institute, 2021
  • Compounds that inhibit the function or proteolytic action of the PROTEASOME.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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