Pharmacologic Substance
amantadine
[ uh-man-tuh-deen ]
Brand Names:
Gocovri; Osmolex
Effect:
Decreased RNA Replication; Increased Central Nervous System Dopamine Activity
May Prevent:
Influenza, Human
May Treat:
Akathisia, Drug-Induced;
Dyskinesia, Drug-Induced;
Dystonia;
Influenza, Human;
Parkinson Disease;
Parkinson Disease, Secondary
More Information:
Definitions related to amantadine:
-
A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.NCI ThesaurusU.S. National Cancer Institute, 2021
-
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
-
Antiviral that is used in the prophylactic or symptomatic treatment of influenza A; it is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia.CRISP ThesaurusNational Institutes of Health, 2006
-
Amantadine, drug used to treat infections caused by influenza type A virus, the most common cause of influenza epidemics. Amantadine and its derivative, rimantadine, can be used successfully in the prevention and treatment of influenza A; however, these agents have no effect against influenza B...Encyclopedia Britannica, Inc., 2020
Return to OpenMD Medical Dictionary
> A
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.