Pharmacologic Substance
amifampridine
Brand Names:
Firdapse; Ruzurgi
Effect:
Increased Central Nervous System Acetylcholine Activity
May Treat:
Lambert-Eaton Myasthenic Syndrome
More Information:
Definitions related to amifampridine:
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4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An organic compound derived from pyridine with potassium channel inhibition activity. Amifampridine inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.NCI ThesaurusU.S. National Cancer Institute, 2021
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