Pharmacologic Substance
amifostine
[ a-mih-fos-teen ]
Brand Names:
Ethyol
Effect:
Parathyroid Gland Activity Alteration
May Prevent:
Acute Kidney Injury; Drug-Related Side Effects and Adverse Reactions; Kidney Failure, Chronic
May Treat:
Radiation Injuries, Experimental
More Information:
Definitions related to amifostine:
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A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.NCI ThesaurusU.S. National Cancer Institute, 2021
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