Pharmacologic Substance
aminophylline
[ uh-mee-noh-fil-ahyn, -een, am-uh-noh- ]
Effect:
Bronchodilation; Inhibition Gastric Acid Secretion; Positive Chronotropy; Renal/Urological Activity Alteration
May Prevent:
Bronchial Spasm
May Treat:
Apnea;
Asthma;
Bradycardia;
Bronchial Spasm;
Bronchitis;
Pulmonary Emphysema
More Information:
Definitions related to aminophylline:
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A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.NCI ThesaurusU.S. National Cancer Institute, 2021
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Drug combination that contains theophylline and ethylenediamine; its most common use is in bronchial asthma, but it has been investigated for several other applications.CRISP ThesaurusNational Institutes of Health, 2006
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