Pharmacologic Substance
aminophylline
[ uh-mee-noh-fil-ahyn, -een, am-uh-noh- ]
Effect:
Bronchodilation; Inhibition Gastric Acid Secretion; Positive Chronotropy; Renal/Urological Activity Alteration
May Prevent:
Bronchial Spasm
May Treat:
Apnea; Asthma; Bradycardia; Bronchial Spasm; Bronchitis; Pulmonary Emphysema
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to aminophylline:
  • A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.
    NCI
    U.S. National Cancer Institute, 2021
  • Drug combination that contains theophylline and ethylenediamine; its most common use is in bronchial asthma, but it has been investigated for several other applications.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.