Antibiotic
amphotericin B
[ am-fuh-ter-uh-sin bee ]
Brand Names:
Abelcet; AmBisome
Effect:
Decreased Cell Wall Integrity
May Prevent:
Mycoses
May Treat:
AIDS-Related Opportunistic Infections;
Aspergillosis;
Blastomycosis;
Candidiasis, Chronic Mucocutaneous;
Candidiasis, Cutaneous;
Coccidioidomycosis;
Cystitis;
Fungemia;
Histoplasmosis;
Leishmaniasis, Visceral;
Meningitis, Cryptococcal;
Neutropenia;
Paracoccidioidomycosis;
Peritonitis;
Sporotrichosis;
Urinary Tract Infections;
Zygomycosis
More Information:
Definitions related to amphotericin b:
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A drug used in the treatment of infections caused by fungi. It is a type of antifungal.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.NCIU.S. National Cancer Institute, 2021
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Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.CRISP ThesaurusNational Institutes of Health, 2006
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