Disease or Syndrome
amyloidosis
am·y·loi·do·sis [ am-uh-loi-doh-sis ]
Subclass of:
Proteostasis Deficiencies
Etymology:
Greek amylon = starch + eidos = resemblance + -osis = condition.
Definitions related to amyloidosis:
-
(amyloid) An accumulation of amyloid protein.CDISC TerminologyClinical Data Interchange Standards Consortium (CDISC), 2021
-
A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.NCI ThesaurusU.S. National Cancer Institute, 2021
-
A group of diseases in which protein builds up in certain organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause), secondary (caused by another disease, including some types of cancer, such as multiple myeloma), or hereditary (passed down from parents to children). Many organs are affected by amyloidosis. The organs affected may depend on whether the amyloidosis is the primary, secondary, or hereditary form.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
-
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
-
Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should. There are three main types of amyloidosis: Primary - with no known cause; Secondary - caused by another disease, including some types of cancer; Familial - passed down through genes. Symptoms can vary, depending upon which organs are affected. Treatment depends on the type of amyloidosis you have. The goal is to help with symptoms and limit the production of proteins. If another disease is the cause, it needs to be treated.MedlinePlusU.S. National Library of Medicine, 2021
-
Any disease manifested by the pathogenic accumulation of amyloid in organs and tissues.CRISP ThesaurusNational Institutes of Health, 2006
-
The presence of amyloid deposition in one or more tissues. Amyloidosis may be defined as the extracellular deposition of amyloid in one or more sites of the body.Human Phenotype Ontology (HPO)The Human Phenotype Ontology Project, 2021
-
Amyloidosis is any of a group of disparate conditions characterized by extracellular deposition of insoluble fibrils composed of misaggregated proteins. These proteins may accumulate locally, causing relatively few symptoms, or widely, involving multiple organs and causing severe multiorgan failure. Amyloidosis can occur de novo or be...Merck & Co., Inc., 2020
-
Amyloid is defined as in vivo deposited material distinguished by the following: Fibrillar appearance on electron micrography Amorphous eosinophilic appearance on hematoxylin and eosin staining (see first image below) Beta-pleated sheet structure as observed by x-ray diffraction pattern Apple-green birefringence on Congo red histological...WebMD, 2019
-
Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when an abnormal protein, called amyloid, builds up in your organs and interferes with their normal function.Mayo Foundation for Medical Education and Research
-
Any histologic tissue specimen that binds the cotton wool dye, Congo red, and demonstrates green birefringence when viewed under polarized light is, by definition, an amyloid deposit. The patient with this deposit has amyloidosis. Deposits of amyloid may be localized in tissue or part of a systemic process. Progressive deposition of...Athenahealth, Inc., 2019
-
Amyloidosis, disease characterized by the deposition of an abnormal protein called amyloid in the connective tissues and organs of the body that inhibits normal functioning. Amyloid is a fibrous, insoluble protein-carbohydrate complex that forms when normally soluble proteins such as antibodies...Encyclopedia Britannica, Inc., 2020
Return to OpenMD Medical Dictionary
> A
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.