Antibiotic
ansamycins
Definitions related to ansamycins:
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An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A group of LACTAMS with an aliphatic ansa chain which is linked to a BENZENE or naphthalene chromophore. Included are RIFAMYCINS, naphthomycins, geldanamycins, streptovaricins, and maytansinoids.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(ansamycin antineoplastic antibiotic) An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins and the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells.NCI ThesaurusU.S. National Cancer Institute, 2021
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