Pharmacologic Substance
antidepressant
an·ti·de·pres·sant [ an-tee-di-pres-uahnt, an-tahy- ]
Subclass of:
Psychotropic Drugs
Also called:
Selective serotonin reuptake inhibitors; SSRIs; Tricyclic antidepressants
Definitions related to antidepressive agents:
-
(antidepressant) A drug used to treat depression.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
-
(antidepressant) A psychiatric drug used to treat mood disorders, such as depression.Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
-
(antidepressants) Antidepressants are prescription medicines to treat depression. Depression is more than feeling a little sad or "blue" for a few days. It's a very common, serious medical illness that affects your mood and general mental health It can make you feel tired, hopeless, worried, or fearful. It can change your thinking, sleeping, and eating. Depression may make some people think about ending their lives. But antidepressants can help many people who have depression. Researchers think antidepressants may help improve the way your brain uses certain chemicals that control mood or stress. A health care provider may prescribe antidepressants for anxiety, chronic pain, or insomnia. Sometimes providers also prescribe antidepressants for other conditions. There are many types of antidepressants. Each one works differently. Providers usually prescribe newer antidepressants first because they don't cause as many side effects as older types. They also seem to help more kinds of depression and anxiety problems. Most of the newer antidepressants belong to one of these three groups: Selective serotonin reuptake inhibitors (SSRIs); Serotonin and norepinephrine reuptake inhibitors (SNRIs); Atypical antidepressants, which are newer antidepressants that don't fit into the other groups. If these antidepressants don't help, your provider might suggest one of the older antidepressants. The older types include tricyclic antidepressants (TCAs), tetracyclics, and monoamine oxidase inhibitors (MAOIs). Even though these antidepressants may cause more serious side effects, the benefits may outweigh the risks for some people. Our bodies and brains all work differently. That means one antidepressant won't work for everyone. You may need to try two or more medicines before you find one that works for you. Your provider will work with you to choose the best option to try first. You'll consider questions such as: Which symptoms bother you most? Some antidepressants may do a better job helping specific symptoms, such as trouble sleeping.; What other medicines and supplements do you take? Some antidepressants can cause problems if you take them with certain medicines and herbs.; Did a certain antidepressant work well for a close relative? An antidepressant that helped a parent, brother, or sister could be a good choice for you, too.; Do you have other health conditions? Certain antidepressants can make some other conditions better or worse. Any other conditions that you have will be part of choosing your depression treatment.; Are you pregnant, planning for pregnancy, or breastfeeding? If so, your provider will help you find a way to treat your depression that's safe for you and your baby. Antidepressants usually take 4 to 8 weeks to work, so you'll need to be patient. You may notice that some problems, such as sleeping and eating, get better before your mood improves. That's a good sign. You may just need to give the medicine a little more time to do its job. Sometimes an antidepressant helps at first, but symptoms return while you're still taking it. But there's usually another one you can try. To get more relief from depression, your provider may suggest combining two antidepressants, using another kind of medicine with an antidepressant, or adding talk therapy or other approaches to improve your mental health. When an antidepressant starts to work, you and your provider can decide how long you need to stay on it. The typical length of treatment is 6 to 12 months, but some people may stay on antidepressants for much longer. Not everyone has side effects from antidepressants. But if you do have them, they're usually mild and may get better over time as your body gets used to the new medicine. The most common side effects from antidepressants include: Nausea and vomiting; Weight gain; Diarrhea; Sleepiness; Sexual problems, such as a...MedlinePlusU.S. National Library of Medicine, 2025
-
(antidepressant agent) A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression.NCIU.S. National Cancer Institute, 2021
-
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2025
-
Antidepressant, any member of a class of drugs prescribed to relieve depression. There are several major classes of antidepressant drugs, the best known of which include the tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRIs). Other...Encyclopedia Britannica, Inc., 2025
Return to OpenMD Medical Dictionary
> A
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.