Pharmacologic Substance
arsenic trioxide
ar·se·nic tri·ox·ide [ ar-seh-nik try-ok-side ]
Brand Names:
Trisenox
Effect:
Decreased DNA Integrity
May Treat:
Leukemia, Promyelocytic, Acute
More Information:
Definitions related to arsenic trioxide:
-
A drug used to treat acute promyelocytic leukemia (APL) that has not gotten better or that has come back after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
-
A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
-
An inorganic compound with the chemical formula As2O3 that is used for the treatment of ACUTE PROMYELOCYTIC LEUKEMIA in patients who have relapsed from, or are resistant to, conventional drug therapy.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
Return to OpenMD Medical Dictionary
> A
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.