• A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2021
• An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system.
  Human Phenotype Ontology (HPO)
  The Human Phenotype Ontology Project, 2021
• Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)
  NCI Thesaurus
  U.S. National Cancer Institute, 2021
• Syndrome including peptic ulcer of the lower esophagus, often with stricture, due to the presence of columnar lined epithelium, which may contain functional mucous cells, parietal cells, or chief cells in the esophagus instead of normal squamous cell epithelium; sometimes pre-malignant, followed by esophageal adenocarcinoma.
  CRISP Thesaurus
  National Institutes of Health, 2006
• (barrett's esophagus) A condition in which the cells lining the lower part of the esophagus have changed or been replaced with abnormal cells that could lead to cancer of the esophagus. The backing up of stomach contents (reflux) may irritate the esophagus and, over time, cause Barrett's esophagus.
  NCI Dictionary of Cancer Terms
  U.S. National Cancer Institute, 2021
• (barrett's esophagus) The abnormal growth of stomach or small intestine cells in the esophagus, resulting from damage caused by the reflux of stomach acid; occasionally may transform into cancer.
  Harvard Dictionary of Health Terms
  Harvard Medical Publishing, 2011
• Barrett esophagus is well recognized as a complication of gastroesophageal reflux disease (GERD). Prolonged exposure of the esophagus to the refluxate of GERD can erode the esophageal mucosa, promote inflammatory cell infiltrate, and ultimately cause epithelial necrosis.
  Medscape
  WebMD, 2019
• Barrett's esophagus is a condition in which the flat pink lining of the swallowing tube that connects the mouth to the stomach (esophagus) becomes damaged by acid reflux, which causes the lining to thicken and become red.
  Mayo Clinic
  Mayo Foundation for Medical Education and Research
• Barrett esophagus is a condition in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestines. Although this change does not cause any specific signs or symptoms, it is typically diagnosed in people who have long-term...
  NIH Genetic and Rare Diseases
  National Center for Advancing Translational Sciences
• Barrett esophagus is a change in the normal squamous epithelium of the esophagus to specialized intestinal metaplasia. This is associated with gastroesophageal reflux, even if the reflux is asymptomatic. Essential to the diagnosis is histology demonstrating columnar-lined epithelium, with or without intestinal metaplasia and with goblet...
  Epocrates
  Athenahealth, Inc., 2019