Pharmacologic Substance
belinostat
[ beh-lih-noh-stat ]
Brand Names:
Beleodaq
Effect:
Increased Cellular Death
May Treat:
Lymphoma, T-Cell, Peripheral
More Information:
Definitions related to belinostat:
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A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance being studied in the treatment of cancer. Belinostat blocks enzymes needed for cell division and may kill cancer cells. It also prevents the growth of blood vessels needed for tumors to grow and may make tumor cells more sensitive to other anticancer drugs. It is a type of histone deacetylase (HDAC) inhibitor, a type of angiogenesis inhibitor, and a type of chemosensitizer.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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