Pharmacologic Substance
bizelesin
[ by-zeh-leh-sin ]
Definitions related to bizelesin:
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A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An anticancer drug that belongs to the family of drugs called alkylating agents. It is also an antitumor antibiotic.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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