Antibiotic
bleomycin Audio
ble·o·my·cin [ blee-uh-mahy-sin ]
Effect:
Decreased DNA Integrity
May Treat:
Carcinoma, Squamous Cell; Choriocarcinoma; Hodgkin Disease; Lymphoma, Non-Hodgkin; Melanoma; Sarcoma; Teratocarcinoma; Testicular Neoplasms
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to bleomycin:
  • A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.
    NCI
    U.S. National Cancer Institute, 2021
  • Complex of related glycopeptide antibiotics from Streptomyces verticillus; inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The active ingredient in a drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It comes from the bacterium Streptomyces verticillus. Bleomycin damages DNA and may kill rapidly growing cancer cells. It is a type of antineoplastic antibiotic.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • (bleomycin antibiotic) A basic glycopeptide antineoplastic antibiotic isolated from Streptomyces verticillus. Bleomycin antibiotics form complexes with iron that react with molecular oxygen to produce superoxide and hydroxyl free radicals, causing single- and double-stranded breaks in DNA. These reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.
    NCI
    U.S. National Cancer Institute, 2021
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