Indicator, Reagent, or Diagnostic Aid
blocking antibody
[ blok-ing an-ti-bod-ee ]
Subclass of:
Antibodies
Definitions related to antibodies, blocking:
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(blocking antibody) An antibody that binds to endogenous or exogenous compounds and inhibits the biological activity of that compound.NCI ThesaurusU.S. National Cancer Institute, 2021
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(blocking antibody) Antibody which interferes with the reactivity of the others by binding available epitopes of homologous specificity; or, univalent antibody that can coat antigen bearing cells but not agglutinate them.CRISP ThesaurusNational Institutes of Health, 2006
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Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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