Organ or Tissue Function
bone remodeling
[ bohn ree-mod-el-ing ]
Subclass of:
Musculoskeletal Physiological Phenomena;
Natural regeneration
Definitions related to bone remodeling:
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A concomitant process in which old bone is resorbed and new bone is formed. Bone remodeling occurs primarily in bone and involves two types of cells, osteoblasts and osteoclasts. Osteoblasts synthesize bone matrix and form new bone while osteoclasts digest mineral matrix and old bone.NCI ThesaurusU.S. National Cancer Institute, 2021
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The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Bone remodeling, continuing process of synthesis and destruction that gives bone its mature structure and maintains normal calcium levels in the body. Destruction, or resorption, of bone by large cells called osteoclasts releases calcium into the bloodstream to meet the body's metabolic needs and...Encyclopedia Britannica, Inc., 2020
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