Vitamin
calcitriol
[ kal-si-tree-awl, -ol ]
Brand Names:
Rocaltrol; Vectical
Effect:
Bone Resorption Inhibition; Decreased Distal Tubule PO4-- Excretion; Decreased Proximal Tubule PO4-- Excretion; Decreased PTH Secretion; Decreased Renal Ca++ Excretion; Stimulation Small Intestine Fluid/Electrolyte Absorption
May Prevent:
Vitamin D Deficiency
May Treat:
Hyperparathyroidism;
Hypocalcemia;
Psoriasis;
Rickets;
Vitamin E Deficiency
More Information:
Definitions related to calcitriol:
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A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types. This agent may be chemopreventive for colon and prostate cancers. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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The active form of vitamin D. Calcitriol is formed in the kidneys or made in the laboratory. It is used as a drug to increase calcium levels in the body in order to treat skeletal and tissue-related calcium deficiencies caused by kidney or thyroid disorders.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(1,25 dihydroxycholecalciferol) Most biologically active metabolite of cholecalciferol; acts via a DNA-binding steroid receptor which induces transcription of calcium transport factors in gut; USP drug (calcitriol) is given as an antihypocalcemic.CRISP ThesaurusNational Institutes of Health, 2006
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