Biologically Active Substance
canfosfamide hcl
Definitions related to canfosfamide hcl:
  • (canfosfamide hydrochloride) A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glutathione analogs.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • (canfosfamide hydrochloride) The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.
    NCI
    U.S. National Cancer Institute, 2021
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