Pharmacologic Substance
captopril
[ kap-tuh-pril ]
Effect:
Decreased Blood Pressure; Decreased Bradykinin Degradation; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Prevent:
Diabetic Nephropathies; Hypertrophy, Left Ventricular; Ventricular Dysfunction, Left
May Treat:
Arthritis, Rheumatoid;
Bartter Syndrome;
Diabetic Nephropathies;
Edema;
Heart Failure;
Hypertension, Malignant;
Raynaud Disease;
Ventricular Dysfunction, Left
More Information:
Definitions related to captopril:
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A drug used to treat high blood pressure that is also being studied in the prevention of side effects caused by radiation therapy used in the treatment of cancer. It belongs to the family of drugs called ACE inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Potent and specific inhibitor of peptidyl dipeptidase A; it acts to suppress the renin-angiotensin system and inhibits blood pressure responses to exogenous angiotensin.CRISP ThesaurusNational Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.