Biologically Active Substance
hydroxyproline
hy·drox·y·pro·line [ hahy-drok-si-proh-leen, -lin ]
May Treat:
Wounds and Injuries
More Information:
Definitions related to hydroxyproline:
-
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
-
A nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen. Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability.NCI ThesaurusU.S. National Cancer Institute, 2021
-
C5H9NO3; amino acid derived from proline, found in collagen and gelatin.CRISP ThesaurusNational Institutes of Health, 2006
-
As a major part of collagen, hydroxyproline has an essential role in collagen stability. Testing hydroxyproline in the serum and in the urine is common.WebMD, 2019
Return to OpenMD Medical Dictionary
> H
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.