Cell Function
cell senescence

[ sel si-nes-uh-un s ]
Subclass of:
Cell physiology;
Aging
Definitions related to cellular senescence:
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(cell aging) An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).Gene Ontology DictionaryGene Ontology Consortium, 2021
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(cell aging) Cellular senescence during AGING or due to extended passages of normal cells in culture and that is triggered by the DNA damage-response to TELOMERE SHORTENING or by repeated exposure to stress signals.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(cell aging) Progression of the cell from its inception to the end of its lifespan.NCI ThesaurusU.S. National Cancer Institute, 2021
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(cell senescence) Final stage of cellular differentiation, characterized by inability to grow, divide, or repair damaged cell components, leading to cell death.CRISP ThesaurusNational Institutes of Health, 2006
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(cell senescence) The end stage in the life of a cell when the cell can no longer divide.Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
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A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.Gene Ontology DictionaryGene Ontology Consortium, 2021
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Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(replicative senescence) A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.Gene Ontology DictionaryGene Ontology Consortium, 2021
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