Pharmacologic Substance
chlorodeoxyadenosine
Brand Names:
Mavenclad
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Multiple Sclerosis
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to cladribine:
  • A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An anticancer drug that belongs to the family of drugs called antimetabolites.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (chlorodeoxyadenosine) Adenosine deaminase-resistant congener of deoxyadenosine with selective toxicity towards lymphocytes and monocytes; used as an immunosuppressive in treating certain leukemias, lymphomas, and autoimmune disorders.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.