Laboratory Procedure
chromosome painting
chro·mo·some paint·ing
Subclass of:
Fluorescent in Situ Hybridization
Definitions related to chromosome painting:
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A technique for visualizing CHROMOSOME ABERRATIONS using fluorescently labeled DNA probes which are hybridized to chromosomal DNA. Multiple fluorochromes may be attached to the probes. Upon hybridization, this produces a multicolored, or painted, effect with a unique color at each site of hybridization. This technique may also be used to identify cross-species homology by labeling probes from one species for hybridization with chromosomes from another species.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Refers to the hybridization of fluorescently labeled, chromosome-specific, composite probe pools to cytological preparations. It allows the visualization of individual chromosomes in metaphase or interphase cells and the identification of both numerical and structural chromosomal aberrations with high sensitivity and specificity. Chromosome painting can be applied to cross-species comparisons as well as to the study of chromosomal rearrangements. The simultaneous hybridization of multiple chromosome painting probes, each tagged with a specific fluorochrome or fluorochrome combination, has resulted in the differential color display of chromosomes, i.e. spectral or color karyotyping. (From Ried et al 1998 Hum Mol Genet 7:1619)NCI ThesaurusU.S. National Cancer Institute, 2021
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