Cell or Molecular Dysfunction
chromosome translocation
chro·mo·some trans·lo·ca·tion [ kroh-muh-sohm trans-loh-kay-shuhn, tranz- ]
Subclass of:
Chromosome Aberrations;
Mutagenesis Process
Definitions related to chromosomal translocation:
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(translocation) A genetic change in which a piece of one chromosome breaks off and attaches to another chromosome. Sometimes pieces from two different chromosomes will trade places with each other. Translocations may lead to medical problems such as leukemia, breast cancer, schizophrenia, muscular dystrophy, and Down syndrome.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(translocation, genetic) A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(chromosome translocation) Rearrangement in which part of a chromosome is detached by breakage and becomes attached to another chromosome.CRISP ThesaurusNational Institutes of Health, 2006
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A genetic exchange where a piece of one chromosome is transferred to another chromosome.NCI ThesaurusU.S. National Cancer Institute, 2021
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(chromosomal translocation process) Any type of genetic recombination involving exchange of DNA between non-homologous chromosomes, which often occurs as the result of non-homologous end-joining of broken DNA strands. Chromosomal translocation is involved in repairing broken DNA and in maintaining cell viability at the expense of long term genomic stability. This process is is associated with particular types of leukemia, infertility and Down Syndrome.NCI ThesaurusU.S. National Cancer Institute, 2021
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