Molecular Biology Research Technique
chromosome walking
Subclass of:
Chromosome Mapping
Definitions related to chromosome walking:
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A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Sequential isolation of clones carrying overlapping sequences of DNA, allowing large regions of the chromosome to be spanned; often performed to reach a particular locus of interest.CRISP ThesaurusNational Institutes of Health, 2006
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