Pharmacologic Substance
ciclopirox
Brand Names:
Ciclodan; CNL8; Loprox; Penlac Nail Lacquer
Effect:
Decreased DNA Replication; Decreased Protein Synthesis; Decreased RNA Replication
May Treat:
Candidiasis, Cutaneous; Onychomycosis; Tinea Pedis; Tinea Versicolor
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to ciclopirox:
  • A cyclohexane and pyridinone derivative that is used for the treatment of fungal infections of the skin and nails, and for treatment of VAGINAL YEAST INFECTIONS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.