Pharmacologic Substance
cilostazol
Effect:
Decreased Platelet Activating Factor Activity; Decreased Platelet Aggregation; Positive Chronotropy; Positive Inotropy; Vasodilation
May Treat:
Graft Occlusion, Vascular; Intermittent Claudication; Peripheral Vascular Diseases
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to cilostazol:
  • A quinoline and tetrazole derivative that acts as a phosphodiesterase type 3 inhibitor, with anti-platelet and vasodilating activity. It is used in the treatment of PERIPHERAL VASCULAR DISEASES; ISCHEMIC HEART DISEASE; and in the prevention of stroke.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A quinolinone derivative and cellular phosphodiesterase inhibitor, more specific for phosphodiesterase III (PDE III). Although the exact mechanism of action of is unknown, cilostazol and its metabolites appears to inhibit PDE III activity, thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. This results in an increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.